Global dissemination of <i>optrA</i> -mediated linezolid resistance in enterococci
This is the first study to investigate the genomic context of optrA in a phylogeographically diverse enterococcal genome collection. We demonstrated that mobile genetic elements play a key role in the global expansion of optrA and highlighted the underlying public health concern imposed by plasmids in drug-resistant enterococcal dissemination.
Authors
- Jessica R. Webb (ORCID: https://orcid.org/0000-0002-6332-039X)
- Christopher Connor (ORCID: https://orcid.org/0000-0002-1761-2412)
- Jia Qi Beh (ORCID: https://orcid.org/0000-0002-6815-7317)
- Benjamin P Howden
Institutions
- The University of Melbourne (AU)
- Peter Doherty Institute (AU)
- Austin Health (AU)
- Melbourne Genomics Health Alliance (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1093/jac/dkag089
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00