Alveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332
Patients with low-risk ASPS (non-metastatic, grossly resected tumors ≤ 5 cm) had excellent outcomes with surgery with or without radiation on ARST0332. Chemotherapy has been reported to be generally ineffective in ASPS and, indeed, there were no objective responses to neoadjuvant chemoradiotherapy on ARST0332. All patients treated with combination chemoradiotherapy ultimately developed disease progression/relapse. A different therapeutic approach is needed for patients with unresectable or metastatic ASPS.
Authors
- Noah Federman (ORCID: https://orcid.org/0000-0002-2627-6772)
- Aaron R. Weiss (ORCID: https://orcid.org/0000-0001-8352-3963)
- Amira Qumseya
- Donald A. Barkauskas (ORCID: https://orcid.org/0000-0002-2339-719X)
- S. Spunt
- Jacquelyn Crane (ORCID: https://orcid.org/0000-0002-8227-5694)
- Kathryn R. Tringale (ORCID: https://orcid.org/0000-0002-1506-4870)
- Rajkumar Venkatramani (ORCID: https://orcid.org/0000-0002-4785-106X)
- Oscar Lopez Nunez
- Thomas Scharschmidt
- Wei Xue
- Jiaqi Hu
Institutions
- University of Southern California (US)
- Nationwide Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- University of California, Los Angeles (US)
- University of California San Diego (US)
- MaineHealth (US)
- Texas Children's Hospital (US)
- Children's Cancer Center (US)
- University of Pennsylvania (US)
- University of Cincinnati Medical Center (US)
- Florida College (US)
- Stanford University (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1002/1545-5017.70228
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00