Effect of circulating exosomal miRNA-122-3p on metabolic dysfunction-associated steatotic liver disease through impairing FGFR4 expression
Exosomal miR-122-3p drives the progression of nonalcoholic fatty liver disease by promoting lipid accumulation, oxidative stress, and suppression of AMPK signaling, primarily through targeting FGFR4. These results identify the miR-122-3p/FGFR4 axis as a potential therapeutic target for treating this condition.
Authors
- Fengyan Wang (ORCID: https://orcid.org/0000-0002-5609-3045)
- Wei J. Wang (ORCID: https://orcid.org/0000-0002-4848-7394)
- Liyun Wang
- Ying Chen
- Lina Ma
- Rongguang Kuang
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Luye Pharma (China) (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1097/cm9.0000000000004003
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00