Impact of trastuzumab deruxtecan (T-DXd) and brain stereotactic radiosurgery on intracranial control and radionecrosis risk in HER2-positive or -low breast cancer brain metastases
Combining T-DXd with SRS demonstrated a favorable safety profile without increasing the risk of radionecrosis. Furthermore, this combination was associated with superior intracranial control, encompassing both local and distant outcomes, supporting the potential of T-DXd combined with SRS as an effective and well-tolerated approach for HER2-positive or -low BCBM.
Authors
- Won Ick Chang (ORCID: https://orcid.org/0000-0002-5268-290X)
- Sun Ha Paek (ORCID: https://orcid.org/0000-0003-3007-8653)
- Ji Hyun Hong (ORCID: https://orcid.org/0000-0002-6237-891X)
- Won Il Jang (ORCID: https://orcid.org/0000-0002-5279-3087)
- Kyung Hwan Shin (ORCID: https://orcid.org/0000-0002-5852-7644)
- Kyubo Kim
- Seok-Joo Chun
- Kyung-Hun Lee
- Yong Bae Kim
- Jieun Lee
- Tae Hyung Kim
- Jin-Ho Song
Institutions
- Yonsei University (KR)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- Korea Institute of Radiological and Medical Sciences (KR)
- Dongguk University Ilsan Hospital (KR)
- National Cancer Center (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- The Breast
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1016/j.breast.2026.104751
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00