Type 2 Inflammation‐Biased Arachidonic Acid Metabolite Regulates Mucosal Remodeling of Chronic Rhinosinusitis With Nasal Polyps
This work establishes the type 2 inflammation-ALOX15-15(S)-HETE-PPAR-γ axis as a key driver of impaired tissue remodeling in ECRSwNP through TGF-β1 suppression. These findings provide novel mechanistic insights into the inflammation-metabolism-remodeling interplay in CRSwNP and highlight promising therapeutic targets for this refractory condition.
Authors
- Huiqing Wang (ORCID: https://orcid.org/0000-0003-0591-2239)
- Yun Ju Yan
- Bangyu Cui
- S Liang
- Chengshuo Wang
- J Cao
- Zhen Chen
- Yang Wang
- Luo Zhang
- Bing Yan
- Ying Li
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Allergy
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1111/all.70301
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00