A Wireless Endovascular Deep Brain Stimulator for Parkinson's Disease

ABSTRACT Deep brain stimulation (DBS) is a well‐established treatment for Parkinson's disease (PD), yet its traditional approaches involving craniotomy and battery implants are highly invasive and pose significant clinical risks. To overcome these limitations, we developed a novel wireless endovascular DBS system (WE‐DBS) that enables minimally invasive, battery‐free stimulation via a vascularly implanted stent electrode and ultrasound‐powered wireless energy transmission. In an MPTP‐induced PD mouse model, WE‐DBS treatment significantly enhanced motor performance and protected dopaminergic neurons in the substantia nigra. Comprehensive electrophysiological characterization confirmed the generation of therapeutically relevant electric fields at the subthalamic nucleus target, with safe charge injection capabilities. Histological analysis revealed no significant tissue damage or neuroinflammation. These results demonstrate WE‐DBS as a promising, minimally invasive alternative for effective and safe neuromodulation in PD.