Leveraging mHealth to Support Physical Exercise in Hematologic Malignancies: A Narrative Review

Background: Hematological malignancies (HMs) and their intensive treatment inevitably lead to physiological decline and cancer-related fatigue. Traditional supervised exercise programs impose transportation costs and cross-infection risks. Consequently, mobile health (mHealth) has emerged as a viable digital delivery modality to overcome these barriers. Aim: This study aims to review research on the use of mHealth to support physical exercise among HM patients and analyze current implementation strategies, clinical value, challenges, and future frameworks. Methods: A comprehensive literature search was conducted across PubMed, Embase, Web of Science, and the Cochrane Library. Data extraction captured key study characteristics, followed by a narrative synthesis approach to analyze all the materials. Results: mHealth technology demonstrated exceptional feasibility and safety, with high completion rates and no serious adverse events reported. Furthermore, mHealth interventions significantly reversed severe physical decline, alleviated cancer-related fatigue, and improved overall health-related quality of life. The most effective interventions utilized a multicomponent architecture and hybrid supervision models. However, several challenges persist, including severe bone destruction risks, the absence of immediate remote emergency support, the digital divide, and technological friction. Conclusion: mHealth exercise interventions demonstrate significant clinical feasibility and efficacy in promoting rehabilitation for HM patients. However, numerous challenges remain at both the theoretical and practical levels. Future research must prioritize adaptive intervention frameworks, integrated clinical ecosystems, and multidisciplinary collaborative care.