Mediation analysis of adiposity and inflammation in the associations of Life’s Crucial 9 and Life’s Essential 8 with mortality among postmenopausal women

We observed inverse associations between LE8 and LC9 scores and both all-cause and cardiovascular mortality in postmenopausal women. Indicators of adiposity and systemic inflammation showed partial statistical mediation of these observed associations.

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Publication Details

Journal
Menopause The Journal of The North American Menopause Society
Published
2026-03-17
DOI
https://doi.org/10.1097/gme.0000000000002761
Primary Topic
Cardiovascular Health and Risk Factors
Type
article
Field-Weighted Citation Impact
0.00
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article

Mediation analysis of adiposity and inflammation in the associations of Life’s Crucial 9 and Life’s Essential 8 with mortality among postmenopausal women

Jun Wei, Yang Liu
Menopause The Journal of The North American Menopause Society
Cardiovascular Health and Risk Factors
article

Mediation analysis of adiposity and inflammation in the associations of Life’s Crucial 9 and Life’s Essential 8 with mortality among postmenopausal women

Jun Wei, Yang Liu
article en

Abstract

We observed inverse associations between LE8 and LC9 scores and both all-cause and cardiovascular mortality in postmenopausal women. Indicators of adiposity and systemic inflammation showed partial statistical mediation of these observed associations.

Menopause The Journal of The North American Menopause Society
Jilin Medical University (CN), Zhejiang University-University of Edinburgh Institute (CN), University of Edinburgh (GB)
Good health and well-being
Openalex Percentile: Top 29%
Cardiovascular Health and Risk Factors
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