Picosecond Laser-Induced Optical Breakdown: A Novel Approach to Reversing Photoaging at the Molecular Level

This investigation establishes consecutive LIOB as a paradigm-shifting therapeutic approach that reverses photoaging through coordinated activation of repair pathways while avoiding thermal damage. The comprehensive molecular mechanisms elucidated provide robust scientific foundation for clinical translation, positioning consecutive picosecond laser technology as a transformative advancement in photoaging treatment with unprecedented efficacy and safety profiles.