Single Saliva Sample Linezolid Dosing for Multidrug-Resistant Tuberculosis: A Population Pharmacokinetic Modelling of Plasma and Saliva
The validated model enables reliable estimation of plasma AUC<sub>0-24</sub> using limited saliva samples. A single saliva sample (pre-dose or 2 h post-dose) can accurately predict plasma AUC<sub>0-24</sub>, supporting saliva-based TDM as a practical alternative to plasma-based monitoring of linezolid in MDR-TB.
Authors
- Dang Luu Vu (ORCID: https://orcid.org/0000-0002-6493-3411)
- Luong Dinh
- Hoa D. Vu
- Tram N. B. Nguyen
- Tri P. Nguyen
- Hoa B. Nguyen
- Greg J. Fox
- Anh Nguyen Thi Nguyen
- Jan-Willem C. Alffenaar
- Thị Thanh Huyền Nguyễn
- Sophie L. Stocker
Institutions
- The University of Sydney (AU)
- Taronga Conservation Society Australia (AU)
- Westmead Hospital (AU)
- St Vincent's Hospital Sydney (AU)
- St Vincent's Clinic (AU)
- Hanoi University of Pharmacy (VN)
- Hanoi Lung Hospital (VN)
- Ho Chi Minh City University of Technology (VN)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1007/s40262-026-01626-4
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00