Layered double hydroxide-supported palladium nanocatalysts in Suzuki-Miyaura coupling: an in-depth review

Abstract The Suzuki-Miyaura cross-coupling reaction is a popular method for generating carbon-carbon bonds in organic synthesis, especially in medicines, agrochemicals, and materials research. Although palladium-based catalysts are central to this transformation, long-standing challenges such as limited stability, metal leaching, recyclability issues and high catalyst cost continue to motivate the development of improved support materials. Layered double hydroxide (LDH) have recently gained significant attention as functional support material due to their tunable composition, large surface area and intrinsic basicity which collectively promote efficient palladium dispersion and enhance catalytic activity. This review highlights the role of LDH in Suzuki-Miyaura reactions by discussing their synthesis, structural features and influence on catalytic performance. The advantages of LDH-supported palladium catalyst including enhanced stability, reduced Pd leaching and excellent recyclability are examined in detail. Overall, this review offers a comprehensive resource for researchers aiming to design sustainable and high-performance catalytic systems for cross-coupling applications.