Daikenchuto ameliorates dextran sulfate sodium-induced acute and chronic ulcerative colitis by regulating gut microbiota-derived indoles to activate AhR signaling
DKT alleviated AC and CUC in mouse models by modulating gut microbiota, restoring Trp metabolism, and activating the AhR/IL-22/STAT3 signaling pathway. These findings provide a basis for the clinical application of DKT in UC patients.
Authors
- Rui Liang (ORCID: https://orcid.org/0000-0002-5095-9637)
- Yinyue Xu
- M Zhang
- Wanghui Jing
- Xia Liu (ORCID: https://orcid.org/0000-0002-9209-0562)
- Hehe Shi
- Qinhua Chen
- Sicen Wang
Institutions
- National Center for Drug Screening (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1186/s13020-026-01358-4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00