A malignant subpopulation of H2AFZ+ cells interacts with myeloid cells to promote an anti-inflammatory microenvironment and drive hepatic metastasis, revealing an immunotherapeutic strategy for pancreatic ductal adenocarcinoma
In conclusion, we reveal a metastasis-associated malignant subpopulation and provide a promising therapeutic strategy for metastatic PDAC.
Authors
- Ling‐Ye Tao
- George Zhang (ORCID: https://orcid.org/0000-0003-2073-7109)
- Wei Liu (ORCID: https://orcid.org/0000-0002-7905-0160)
- Ying Liu
- Jian‐Yu Yang
- Ping Lin
- Zonghao Duan
- Yongwei Sun
- Linli Yao
- Hong Li
- Minwei Yang
- Yanmiao Huo
- Wanhong Chen
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Institute of Nutrition and Health (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-3359
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China