Comparative effectiveness of three linezolid management strategies for peripheral neuropathy during multidrug- or rifampicin-resistant tuberculosis treatment
We did not find evidence of a substantial negative impact of immediate modification to linezolid among people who developed mild or moderate peripheral neuropathy in the first six months of an individualized regimen. Our results support the clinical practice of cautiously adjusting linezolid when needed to manage non-severe peripheral neuropathy.
Authors
- Aga Krisnanda
- Letizia Trevisi
- Matthew L. Romo (ORCID: https://orcid.org/0000-0002-3038-0644)
- Palwasha Khan (ORCID: https://orcid.org/0000-0002-0873-8355)
- Tinatin Kotrikadze
- Hakob Atshemyan (ORCID: https://orcid.org/0000-0003-4900-3096)
- Norbert Ndjeka (ORCID: https://orcid.org/0000-0001-6200-1592)
- Lawrence Oyewusi
- Carole D. Mitnick (ORCID: https://orcid.org/0000-0002-3455-658X)
- Catherine Hewison (ORCID: https://orcid.org/0000-0002-0363-1479)
- Michael Rich (ORCID: https://orcid.org/0000-0003-4333-4695)
- Nazgul Samieva (ORCID: https://orcid.org/0009-0008-4922-7130)
- Malik Adenov
- Mahmud Rashitov
- Abdul Wali Khan (ORCID: https://orcid.org/0000-0003-1008-3973)
- Kwonjune J. Seung (ORCID: https://orcid.org/0000-0003-0417-4625)
- Camilo Gómez-Restrepo
- Edwin Herrera Flores
- Uzma Khan
- Faisal Siraj
- Molly F Franke
- Andargachew Kumsa
- Allison LaHood
- Mathieu Bastard
- Helena Huerga
- Alena Skrahina
Institutions
- Almaty Management University (KZ)
- University of London (GB)
- Partners In Health (US)
- Médecins Sans Frontières (UG)
- Harvard University (US)
- McGill University Health Centre (CA)
- London School of Hygiene & Tropical Medicine (GB)
- Hospital Nacional Cayetano Heredia (PE)
- Ministry of National Health Services Regulation and Coordination (PK)
- Ministry of Justice of the Republic of Kazakhstan (KZ)
- Department of Health (ZA)
- Ministry of Health (LS)
- Interactive Research and Development (PK)
- Harvard Global Health Institute (US)
- Médecins Sans Frontières (FR)
- Belarusian National Technical University (BY)
- Armenian State Pedagogical University after Khachatur Abovian (AM)
Publication Details
- Journal
- medRxiv
- Published
- 2026-03-16
- DOI
- https://doi.org/10.64898/2026.03.14.26348377
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00