Short Antibiotic Treatment for Coagulase-negative Staphylococcal Sepsis in Premature Infants: A Multicenter Noninferiority Study

The relapse rate in uncomplicated CoNS sepsis was extremely low (<1%), even with short-course treatment. In premature infants with uncomplicated CoNS sepsis, shorter antibiotic treatment is noninferior to longer treatment, confirming its safety and effectiveness.

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Publication Details

Journal
The Pediatric Infectious Disease Journal
Published
2026-03-16
DOI
https://doi.org/10.1097/inf.0000000000005209
Primary Topic
Neonatal and Maternal Infections
Type
article
Field-Weighted Citation Impact
0.00
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article

Short Antibiotic Treatment for Coagulase-negative Staphylococcal Sepsis in Premature Infants: A Multicenter Noninferiority Study

Klasien A. Bergman, Tom F.W. Wolfs, Matthias Christian Hütten, M A C Hemels et al.
The Pediatric Infectious Disease Journal
Neonatal and Maternal Infections
article

Short Antibiotic Treatment for Coagulase-negative Staphylococcal Sepsis in Premature Infants: A Multicenter Noninferiority Study

Klasien A. Bergman, Tom F.W. Wolfs, Matthias Christian Hütten, M A C Hemels, Douwe H. Visser, Vincent Bekker, Ingrid M. Nijholt, René F. Kornelisse, S. B. Debast, John W.A. Rossen, Carmen Lorente Flores, Jacqueline U.M. Termote, Esther J. d’Haens, Yvette G.T. Loeffen
article en

Abstract

The relapse rate in uncomplicated CoNS sepsis was extremely low (<1%), even with short-course treatment. In premature infants with uncomplicated CoNS sepsis, shorter antibiotic treatment is noninferior to longer treatment, confirming its safety and effectiveness.

The Pediatric Infectious Disease Journal
University Medical Center Groningen (NL), Radboud University Nijmegen (NL), University of Groningen (NL), Leiden University Medical Center (NL), Maastricht University Medical Centre (NL), Erasmus MC (NL), Emma Kinderziekenhuis (NL), Beatrix Kinderziekenhuis (NL), Máxima Medisch Centrum (NL), Erasmus MC - Sophia Children’s Hospital (NL), Isala (NL), Amsterdam University Medical Centers (NL), Wilhelmina Children's Hospital (NL), University of Amsterdam (NL)
Good health and well-being
Openalex Percentile: Top 24%
Neonatal and Maternal Infections
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