A novel role for decadienyl-L-carnitine in pulmonary vascular remodeling and the underlying interventional mechanism of osthole
Our study identifies a novel function of C10:2 in promoting pyroptosis and accelerating pulmonary vascular remodeling through activation of the HSP47/NLRP3 axis. Furthermore, we demonstrate that osthole effectively inhibits C10:2/HSP47/NLRP3 axis-induced pyroptosis, thereby alleviating pulmonary vascular remodeling. These findings suggest that C10:2 may serve as a potential biomarker for PH diagnosis and provide a foundation for the development of novel anti-PH therapeutic strategies.
Authors
- Li Yao (ORCID: https://orcid.org/0000-0002-1120-8435)
- Jiaoxia WEI
- Dongyang Han
- Jiayi Liu (ORCID: https://orcid.org/0000-0003-1819-2998)
- Yuan Li
- Yuxin Qiao
- Haitao Lu
Institutions
- Hong Kong Baptist University (HK)
- Harbin Medical University (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1186/s13020-026-01362-8
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harbin Medical University
- Shanghai Jiao Tong University
- Natural Science Foundation of Heilongjiang Province
- Fundamental Research Funds for the Central Universities