Costimulatory blockade depletes T peripheral helper, late-activated naïve, and DN2 B cells in rheumatoid arthritis
Multi-omics analyses showed costimulatory blockade depletes trafficking DN2 B cells and Tph cells that correlates with rheumatoid disease response.
Authors
- Abhimanyu Amarnani (ORCID: https://orcid.org/0000-0001-9548-595X)
- Kelly V. Ruggles (ORCID: https://orcid.org/0000-0002-0152-0863)
- Jasmine Shwetar
- W. Rigby
- Sladjana Skopelia-Gardner
- Gregg J. Silverman
Institutions
- Dartmouth–Hitchcock Medical Center (US)
- New York University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-03-16
- DOI
- https://doi.org/10.64898/2026.03.14.26348386
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health