Auxiliary TARP Subunits Define AMPA Receptor Pharmacology and Function
The present study describes a specific kinetic mechanism by which dibenzobarrelene derivatives impair the function of the AMPA receptor and its dependence on auxiliary proteins. The present study provides a mechanistic understanding of AMPA receptor gating modulation and establishes a pharmacological framework for future investigations in more physiologically relevant systems.
Authors
- Sosana Bdir (ORCID: https://orcid.org/0000-0002-0540-1773)
- Mohammed Hawash (ORCID: https://orcid.org/0000-0001-5640-9700)
- Mohammad Qneibi (ORCID: https://orcid.org/0000-0002-0702-7834)
- İrfan Çapan (ORCID: https://orcid.org/0000-0002-9555-1555)
- Süleyman Servi
Institutions
- Ankara University (TR)
- An-Najah National University (PS)
- Gazi University (TR)
Publication Details
- Journal
- Journal of Xenobiotics
- Published
- 2026-03-16
- DOI
- https://doi.org/10.3390/jox16020050
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- An-Najah National University