Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ
DOTA-ATH022 is a novel dimerized version of ATH001, with significantly improved affinity towards PDGFRβ. Retention of radiolabeled DOTA-ATH022 in PDGFRβ-avid tissues and tumors was increased, however uptake in solid tumor tissue was not improved.
Authors
- Tahmida Akter
- Natalia Papadopoulos (ORCID: https://orcid.org/0000-0001-5781-5524)
- Olof Eriksson (ORCID: https://orcid.org/0000-0002-2515-8790)
- Ayman Abouzayed
- Olle Korsgren (ORCID: https://orcid.org/0000-0002-8524-9547)
- John Löfblom (ORCID: https://orcid.org/0000-0001-9423-0541)
- Hemantha Mallapura (ORCID: https://orcid.org/0000-0002-7325-4314)
- Bogdan Mitran (ORCID: https://orcid.org/0000-0001-7921-3268)
- Irina Velikyan
- Michael Wagner
- Hugo Olsson
- Carl-Henrik Heldin
Institutions
- Uppsala University (SE)
- Ericsson (Sweden) (SE)
- Uppsala University Hospital (SE)
- Science for Life Laboratory (SE)
- Akademiska Barnsjukhuset (SE)
- Antaros Medical (Sweden) (SE)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1186/s41181-026-00439-x
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00