UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation and predispose to intestinal inflammation

Authors

Thomas H. Edwards (ORCID: https://orcid.org/0000-0002-1706-9536)
Adarsh B. Manjunath
Kayla J. Fasano (ORCID: https://orcid.org/0000-0002-5802-8140)
Megan E. Smithmyer (ORCID: https://orcid.org/0000-0002-1005-0621)
Lin Wei Tung

Institutions

University of Washington (US)
Benaroya Research Institute

Publication Details

Journal: bioRxiv (Cold Spring Harbor Laboratory)
Published: 2026-03-15
DOI: https://doi.org/10.64898/2026.03.12.709585
Primary Topic: Inflammatory Bowel Disease
Type: article
Field-Weighted Citation Impact: 0.00

Funders

M.J. Murdock Charitable Trust
Fred Hutchinson Cancer Research Center
University of Washington
Kenneth Rainin Foundation
National Institutes of Health
National Institute of Allergy and Infectious Diseases
National Institute of Diabetes and Digestive and Kidney Diseases

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article

UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation and predispose to intestinal inflammation

Thomas H. Edwards, Adarsh B. Manjunath, Kayla J. Fasano, Megan E. Smithmyer et al.

Mar 15, 2026

bioRxiv (Cold Spring Harbor Laboratory)

Inflammatory Bowel Disease

article

UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation and predispose to intestinal inflammation

Thomas H. Edwards, Adarsh B. Manjunath, Kayla J. Fasano, Megan E. Smithmyer, Lin Wei Tung

March 15, 2026article en

Abstract

No abstract available for this paper.

bioRxiv (Cold Spring Harbor Laboratory)

University of Washington (US), Benaroya Research Institute

M.J. Murdock Charitable Trust, Fred Hutchinson Cancer Research Center, University of Washington, Kenneth Rainin Foundation, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases

Good health and well-being

Openalex Percentile: Top 20%

Inflammatory Bowel Disease

DOI Open Access PDF OpenAlex

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