Impact of mechanical ventilation on oxidative stress, neuroinflammation, memory and anxiety related behavior: Insights from an experimental model
The relationship between oxidative stress, neuroinflammation, and behavioral changes validates the hypothesis that the ventilator-induced lung injury effects extend beyond the lungs, impairing brain function and leading to cognitive deficits. This study advances current knowledge by showing that even short periods of mechanical ventilation can trigger early neurobehavioral changes. These findings underscore the need for protective ventilation strategies to minimize the systemic effects of mechanical ventilation.
Authors
- Alberto F. De Souza (ORCID: https://orcid.org/0000-0003-1561-8447)
- Aline Maria dos Santos (ORCID: https://orcid.org/0000-0002-6365-4787)
- F. C. Silva
- Alexandre Barbosa Reis (ORCID: https://orcid.org/0000-0001-8123-4164)
- Pedro Alves Machado-Júnior (ORCID: https://orcid.org/0000-0002-9333-9112)
- Rodrigo Cunha Alvim de Menezes (ORCID: https://orcid.org/0000-0003-0286-0621)
- Leandro da Silva Cândido (ORCID: https://orcid.org/0000-0002-6324-7698)
- Matheus Ramos Lopes
- Frank Silva Bezerra
- Thais Lopes Valetim Di Paschoale Ostolin
- Deoclécio Alves Chianca-Jr
Institutions
- Universidade Federal de Ouro Preto (BR)
Publication Details
- Journal
- Respiratory Physiology & Neurobiology
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1016/j.resp.2026.104565
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00