AortaExplorer: AI-driven analysis of the aorta in CT images

We introduce AortaExplorer, an open-source, fully automated AI-driven framework for end-to-end aortic analysis from computed tomography angiography (CTA) scans. AortaExplorer extracts established biomarkers, such as diameters across anatomical segments, and introduces novel metrics, including aortic tortuosity. Diameter measurements were validated against expert manual readings in more than 10,000 CTA scans from Danish population cohorts, demonstrating high accuracy. The computed descending aortic tortuosity index aligns with trends reported in previous studies, confirming its increase with age. By reducing analysis time from approximately 15 minutes per case to under five minutes, AortaExplorer enables efficient, reproducible assessment of aortic morphology at scale. This tool supports clinical research and large cohort studies by combining state-of-the-art segmentation performance with extensive visualization and quantitative reporting.