Telocyte Deletion is Associated with Loss of Lymphatic Drainage and Exacerbation of Inflammatory‐Erosive Arthritis in Mice

Telocyte networks extend from the synovium into mast cells proximal to joint-draining cLVs, and telocyte loss is associated with synovial lymphatic system (SLS) defects and exacerbated joint pathology from inflammatory-erosive arthritis. Thus, SLS telocytes are a novel drug target for RA and interventions that maintain telocytes (e.g. exercise) may improve lymphatic function.