Early Combination Antiretroviral Therapy Initiation During Primary HIV Infection Restricts HIV Reservoirs and Gut-Driven Inflammation but Fails to Rewire the Systemic Cytokine Landscape
Early cART initiation in individuals with PHI reduces viral reservoirs and limits gut barrier disruption and microbial translocation but fails to restore the systemic cytokine landscape compared with PWOH. These findings support the benefits of prompt treatment initiation during acute infection to limit HIV reservoir size and preserve mucosal integrity.
Authors
- Arianna Gabrieli (ORCID: https://orcid.org/0000-0002-2657-8025)
- Stefania Dispinseri (ORCID: https://orcid.org/0000-0003-1495-6778)
- Gabriella Scarlatti (ORCID: https://orcid.org/0000-0003-2316-2689)
- Roberta Rovito (ORCID: https://orcid.org/0000-0002-8640-844X)
- Valentina Sala (ORCID: https://orcid.org/0000-0002-2283-2807)
- Camilla Tincati (ORCID: https://orcid.org/0000-0002-3083-2962)
- Andrea Calcagno (ORCID: https://orcid.org/0000-0003-2534-8815)
- Matteo Augello (ORCID: https://orcid.org/0000-0002-1031-9504)
- Antonio Muscatello (ORCID: https://orcid.org/0000-0002-2428-6432)
- Valeria Bono (ORCID: https://orcid.org/0000-0003-2182-5434)
- Elena Bruzzesi (ORCID: https://orcid.org/0000-0002-3601-7686)
- Alessandra Bandera (ORCID: https://orcid.org/0000-0003-1626-0328)
- A. Gori
- A Giacomelli
- Silvia Nozza
- Stefano Rusconi
- Giulia Carla Marchetti
Institutions
- AOL (United States) (US)
- Vita-Salute San Raffaele University (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Maggiore (IT)
- Department of Medical Sciences (BY)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- ASST Fatebenefratelli Sacco (IT)
- Azienda Ospedaliera Ospedale Civile di Legnano (IT)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1093/ofid/ofag077
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00