The futility of the familiar: rethinking strategies for the development of small molecules for neurodegenerative disorders
Conventional approaches in CNS drug discovery and development have not yielded disease-modifying CNS drugs. To be successful, it is important to rethink strategies, assays, animal models from scratch and redesign how R&D in CNS diseases should be carried out.
Authors
- CY Chai
- Manuel Novás (ORCID: https://orcid.org/0009-0008-4678-1339)
- Maria João Matos
Institutions
- National University of Singapore (SG)
- Universidade de Santiago de Compostela (ES)
Publication Details
- Journal
- Expert Opinion on Drug Discovery
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1080/17460441.2026.2646603
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00