Qiming granules regulate Müller cell pyroptosis and the P2X7R/NLRP3 immune inflammatory pathway in diabetic retinopathy
QMG mitigated Müller cell pyroptosis and inflammatory responses by regulating the P2X7R/NLRP3 pathway, thereby inhibiting early neurodegeneration in DR. Astragaloside IV and puerarin absorbed into systemic circulation, significantly attenuated high glucose-induced pyroptosis, and suppressed immunoinflammatory responses in Müller cells.
Authors
- Guiqi Yang
- Hongbin Lv
- Qi Zhou (ORCID: https://orcid.org/0000-0001-7884-7074)
- H Ye
- Fang Wang
- Min Tang
- Yaping Wang
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1186/s13020-026-01370-8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Southwest Medical University