Advancing Sterilization of Medical Implant Polymers: Novel Low-Temperature Deep-vacuum Vaporized H2O2 Technology Surpasses Current Methods
Deep vacuum VH₂O₂ sterilization at room temperature is feasible, with vacuum level critical for maintaining scaffold integrity. LV sterilization effectively preserves morphology in PLC and TPU, while HV is also reliable for less sensitive polymers. Chemical and molecular properties remain unaffected, supporting VH₂O₂ sterilization as a gentle and effective promising method for implantable textile-based biomaterials.
Authors
- Sergio Crotti
- Mariella Rosalia (ORCID: https://orcid.org/0000-0002-3677-3393)
- Abinaya Nallathambi (ORCID: https://orcid.org/0009-0007-3491-1602)
- Enrica Chiesa (ORCID: https://orcid.org/0000-0002-6248-3795)
- A. Tamborini (ORCID: https://orcid.org/0000-0002-6396-4283)
- Ida Genta (ORCID: https://orcid.org/0000-0001-5710-0588)
- Giovanna Bruni (ORCID: https://orcid.org/0000-0003-1958-2998)
Institutions
- University of Pavia (IT)
- Martin University (US)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1007/s11095-026-04063-x
- Primary Topic
- Electrospun Nanofibers in Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Università degli Studi di Pavia