Signal peptide variation in cyst lectins as a potential marker for pathogenic Acanthamoeba spp.

Our findings reveal previously underexplored sequence diversity in cyst wall lectins across Acanthamoeba isolates. This diversity may contribute to differences in cyst wall architecture between clinical and environmental isolates. These results provide new insight into cyst-associated molecular features that may be linked to pathogenic potential and offer a foundation for future studies on cyst-mediated adaptation and infection.