Improved hemodynamic and cardiorespiratory instability with vitamin D supplementation in an obstructive sleep apnea rat models
Vitamin D deficiency combined with intermittent hypoxia increased mean arterial pressure, heart rate, and respiratory rate, reduced oxygen saturation, and worsened cardiovascular histology. Vitamin D supplementation improved these changes, especially at higher dose, and protected cardiovascular structures.
Authors
- Syed Shahid Habib (ORCID: https://orcid.org/0000-0001-5944-8406)
- Yasser A. Alshawakir
- Alanoud T. Aljasham (ORCID: https://orcid.org/0000-0002-6564-7732)
- Hayam I. Gad
- Tamadar Abdulrhman Al Doheyan
- Mubarak Saad Aldosary
- Abdulmueen A. Alotaibi
- Abeer AbdulMoati Al-Masri
- Asma F. Alotaibi
Institutions
- Alfaisal University (SA)
- King Saud University (SA)
- King Khalid University Hospital (SA)
- National Guard Health Affairs (SA)
Publication Details
- Journal
- Saudi Pharmaceutical Journal
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1007/s44446-026-00074-2
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AlMaarefa University
- King Saud University