Hepatic STEAP4 promotes liver regeneration by regulating lysosomal iron homeostasis and membrane integrity in acetaminophen-induced liver injury
STEAP4 is not essential during the early injury phase but plays a critical role in liver regeneration by maintaining lysosomal iron homeostasis and function after APAP overdose. Targeting STEAP4-mediated endolysosomal iron overload may open new therapeutic avenues for AILI.
Authors
- Haifeng Xu (ORCID: https://orcid.org/0009-0005-6689-1277)
- Peng Cao (ORCID: https://orcid.org/0000-0002-2044-3074)
- Chen Zhang (ORCID: https://orcid.org/0000-0001-7609-980X)
- Hao Zhu (ORCID: https://orcid.org/0000-0002-6507-8904)
- Wanqing Liu
- H. Y. Zhu
- Hong-Min Ni
- Wen-Xing Ding
- Mengwei Niu
Institutions
- Eugene Applebaum College of Pharmacy and Health Sciences (US)
- Wayne State University (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Hepatology
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1097/hep.0000000000001718
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00