Comparative genomic analyses of <i>Escherichia coli</i> ST405 strains from Pakistan
This study provides a comprehensive genomic landscape of ST405, a high-risk international clone and a carrier of the <i>bla</i><sub>NDM-5</sub> gene, revealing phylogenetically distinct patterns in the distribution of antibiotic resistance genes and virulence factors, and a critical phylogenetic lineage that serves as a primary reservoir of the <i>bla</i><sub>NDM-5</sub> gene. Furthermore, the genetic linkage between ST405 and other STs (ST156 and ST648) through the sharing of identical <i>bla</i><sub>NDM-5</sub>-carrying plasmids, and the emergence of a novel <i>bla</i><sub>NDM-5</sub> genetic structure in an animal isolate, underscore the pivotal role of ST405 in the dissemination of the <i>bla</i><sub>NDM-5</sub> gene. These findings highlight the public health significance of ST405 and its contribution to the global spread of carbapenem resistance.
Authors
- Nam‐Hoon Kim (ORCID: https://orcid.org/0000-0001-5042-8214)
- Dae-Wi Kim
- Gwangje Lee
- Abdul Rauf Tareen (ORCID: https://orcid.org/0000-0002-3991-020X)
- Saba Yasmin
- J. Jack Lee (ORCID: https://orcid.org/0000-0001-5469-9214)
- Dongwon Lee (ORCID: https://orcid.org/0000-0003-3035-6342)
- Sang Hee Lee (ORCID: https://orcid.org/0000-0002-5660-7122)
- Byeonghyeon Kang
- Chanyeong Jeong
- Rabaab Zahra
- Kyung-Min Jang
Institutions
- Quaid-i-Azam University (PK)
- Jeonbuk National University Hospital (KR)
- St. James's Hospital (IE)
- Jeonbuk National University (KR)
- Myongji University (KR)
Publication Details
- Journal
- mSystems
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1128/msystems.01685-25
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00