An inflammatory biomarker panel for prediabetes classification using interpretable machine learning

Our findings introduce a novel panel of inflammatory biomarkers that show promise in the identification of prediabetes independently of traditional glucose-based measures. By highlighting inflammation as an early indicator of metabolic dysfunction, this approach may enhance precision in the detection of prediabetes. Longitudinal studies with larger and more diverse populations are essential to clinically validate these biomarkers and confirm their value in improving the early diagnosis and management of metabolic health.

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Publication Details

Journal
PLoS ONE
Published
2026-03-16
DOI
https://doi.org/10.1371/journal.pone.0341195
Primary Topic
Adipokines, Inflammation, and Metabolic Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

An inflammatory biomarker panel for prediabetes classification using interpretable machine learning

Maher Maalouf, Maram Tammam, Asmaa Alsereidi, Herbert F. Jelinek et al.
PLoS ONE
Adipokines, Inflammation, and Metabolic Diseases
article

An inflammatory biomarker panel for prediabetes classification using interpretable machine learning

Maher Maalouf, Maram Tammam, Asmaa Alsereidi, Herbert F. Jelinek, Muhammad Afzal, Sana Kurungadan
article en

Abstract

Our findings introduce a novel panel of inflammatory biomarkers that show promise in the identification of prediabetes independently of traditional glucose-based measures. By highlighting inflammation as an early indicator of metabolic dysfunction, this approach may enhance precision in the detection of prediabetes. Longitudinal studies with larger and more diverse populations are essential to clinically validate these biomarkers and confirm their value in improving the early diagnosis and management of metabolic health.

PLoS ONEVol. 21(3)
Khalifa University of Science and Technology (AE)
Openalex Percentile: Top 22%
Adipokines, Inflammation, and Metabolic Diseases
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An inflammatory biomarker panel for prediabetes classification using interpretable machine learning — Maher Maalouf, Maram Tammam, et al. · PLoS ONE (2026) | TGRS Research Map | TGRS