HIF-1α Drives Cellular Senescence Via Autophagy Activation to Promote AKI-to-CKD Transition
Adequate HIF-1α activation during early AKI is associated with acute senescence and renal repair, whereas sustained HIF-1α drives chronic senescence via persistent autophagy activation, and may contribute to the AKI-to-CKD transition.
Authors
- Lingxu Li
- Xiaoying Yun (ORCID: https://orcid.org/0000-0003-0428-7195)
- M Zhang (ORCID: https://orcid.org/0009-0004-3876-5444)
- Meiting Wu (ORCID: https://orcid.org/0009-0003-1790-6271)
- Bing Li
- Chang Wang
- Xinyue Mao
Publication Details
- Journal
- American Journal of Nephrology
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1159/000551542
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China