PAK5-Mediated Suppression of β-Hydroxybutyrate Production Promotes Breast Cancer Metastasis and Can Be Overcome with Ketogenic Diet
PAK5-mediated phosphorylation of HMGCS2 promotes breast cancer growth and metastasis by inhibiting β-hydroxybutyrate production, revealing the role of PAK5 in ketone metabolism and highlighting a potential therapeutic target for breast cancer metastasis.
Authors
- Shulan Sun (ORCID: https://orcid.org/0000-0002-7624-1797)
- Bei Hu
- Fuyi Han
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Yao Xing (ORCID: https://orcid.org/0009-0002-8625-2753)
- Yanshu Li (ORCID: https://orcid.org/0009-0005-1367-7883)
- Yongqiang Tan
- Yidu Liu
- Feng Li
- Yang Li
- Xu Wang
- Jinyu Zuo
Institutions
- National Health and Family Planning Commission (CN)
- General Hospital of Shenyang Military Region (CN)
- First Hospital of China Medical University (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1158/0008-5472.can-25-2174
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00