Visible‐Light Mediated Functionalization in Phe‐Containing Peptides Upon a Debenzylative Amination Process
An efficient protocol for the modification of phenylalanine‐containing peptides is developed. The tandem debenzylation–amination process in N‐terminal phenylalanine short peptides with N ‐iodoimides proceeds under visible‐light irradiation and metal‐free conditions. This method broadens the available chemical toolbox for the modification of Phe and allows the incorporation of N‐containing heterocycles into peptide settings.
Authors
- Javier Carreras (ORCID: https://orcid.org/0000-0002-1521-6758)
- Enrique Gómez‐Bengoa (ORCID: https://orcid.org/0000-0002-8753-3760)
- Arkaitz Correa (ORCID: https://orcid.org/0000-0002-9004-3842)
- Iván Pérez‐Cubero
- Guillermo Morales‐Ortega
Institutions
- University of the Basque Country (ES)
- Universidad de Alcalá (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1002/adsc.70352
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00