Metabolic Syndrome Duration and Risk of Frailty among Midlife Women: The Study of Women’s Health Across the Nation (SWAN)

Among women in this multiethnic cohort, MetSyn was common during midlife and strongly associated with future development of pre-frailty and frailty while women were in their early sixties. Measurement of MetSyn during midlife can help identify women at high risk for developing frailty early in the aging process.

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Publication Details

Journal
The Journals of Gerontology Series A
Published
2026-03-11
DOI
https://doi.org/10.1093/gerona/glag058
Primary Topic
Frailty in Older Adults
Type
article
Field-Weighted Citation Impact
0.00
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article

Metabolic Syndrome Duration and Risk of Frailty among Midlife Women: The Study of Women’s Health Across the Nation (SWAN)

M. S. S. Brooks, Carol A. Derby, Elizabeth A. Jackson, E Strotmeyer et al.
The Journals of Gerontology Series A
Frailty in Older Adults
article

Metabolic Syndrome Duration and Risk of Frailty among Midlife Women: The Study of Women’s Health Across the Nation (SWAN)

M. S. S. Brooks, Carol A. Derby, Elizabeth A. Jackson, E Strotmeyer, Brittney Lange-Maia, Carrie A Karvonen-Gutierrez, Michelle M Hood, Daniel H Solomon
article en

Abstract

Among women in this multiethnic cohort, MetSyn was common during midlife and strongly associated with future development of pre-frailty and frailty while women were in their early sixties. Measurement of MetSyn during midlife can help identify women at high risk for developing frailty early in the aging process.

The Journals of Gerontology Series A
Brigham and Women's Hospital (US), Rush University Medical Center (US), Albert Einstein College of Medicine (US), University of Pittsburgh (US), University of Michigan (US), University of Alabama at Birmingham (US), Michigan Medicine (US)
Gender equality
Openalex Percentile: Top 20%
Frailty in Older Adults
DOISourceOpenAlex
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Metabolic Syndrome Duration and Risk of Frailty among Midlife Women: The Study of Women’s Health Across the Nation (SWAN) — M. S. S. Brooks, Carol A. Derby, et al. · The Journals of Gerontology Series A (2026) | TGRS Research Map | TGRS