The interaction between sarcoplasmic reticulum and mitochondria: a novel mechanism for cardiac arrhythmia

Cardiovascular diseases are a major cause of morbidity and mortality worldwide. Cardiac arrhythmias, especially fatal ventricular arrhythmias, are highly harmful to patients and can even lead to sudden death. While electrical and structural remodeling of myocardial tissue represent the mainstream mechanisms underlying arrhythmogenesis, there is a critical need to explore novel perspectives. This review focuses on the communication between the sarcoplasmic reticulum and mitochondria as an independent mechanistic lens. We detail how this specific interaction governs Ca 2+ transfer and cell-death signaling, positioning it as a potentially pivotal, distinct pathway that contributes to and amplifies the development of cardiac arrhythmias.