RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation

RHOT proteins bind mitochondria to contractile muscle fiber proteins and are required for mitochondrial positioning in cardiomyocytes during development. Our study links mitochondrial motility and local ATP production to structural and functional maturation of the heart.

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Publication Details

Journal
Circulation Research
Published
2026-03-16
DOI
https://doi.org/10.1161/circresaha.125.327297
Primary Topic
Mitochondrial Function and Pathology
Type
article
Field-Weighted Citation Impact
0.00
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article

RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation

Mark Kühnel, Natali Froese, Theresa Schweitzer, Christoph Wrede et al.
Circulation Research
Mitochondrial Function and Pathology
article

RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation

Mark Kühnel, Natali Froese, Theresa Schweitzer, Christoph Wrede, Malgorzata Szaroszyk, Alexander Froese, Johanna Schneider, Christian Riehle, Maren Heimerl, Danny Jonigk, Robert Geffers, Paolo Galuppo, Viacheslav O. Nikolaev, Ivanna Shymotiuk, Christopher Werlein, Jan Hegermann, Sergej Erschow, Tim Scholz, Felix Polten, Kai C. Wollert, Adam R. Wende, Anna Gigina, Andreas Pich, Mortimer Korf-Klingebiel, Melanie Ricke-Hoch, Katharina Wihler, Jonas Jablinski, E. Dale Abel, Johann Bauersachs
article en

Abstract

RHOT proteins bind mitochondria to contractile muscle fiber proteins and are required for mitochondrial positioning in cardiomyocytes during development. Our study links mitochondrial motility and local ATP production to structural and functional maturation of the heart.

Circulation Research
Universität Hamburg (DE), UCLA Health (US), University Medical Center Freiburg (DE), University of Alabama at Birmingham (US), Medizinische Hochschule Hannover (DE), University Medical Center Hamburg-Eppendorf (DE), Helmholtz Centre for Infection Research (DE), German Center for Lung Research (DE)
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Openalex Percentile: Top 20%
Mitochondrial Function and Pathology
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