RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation
RHOT proteins bind mitochondria to contractile muscle fiber proteins and are required for mitochondrial positioning in cardiomyocytes during development. Our study links mitochondrial motility and local ATP production to structural and functional maturation of the heart.
Authors
- Mark Kühnel (ORCID: https://orcid.org/0000-0003-3558-2576)
- Natali Froese
- Theresa Schweitzer
- Christoph Wrede (ORCID: https://orcid.org/0000-0001-7461-6965)
- Malgorzata Szaroszyk (ORCID: https://orcid.org/0009-0008-4051-3958)
- Alexander Froese
- Johanna Schneider (ORCID: https://orcid.org/0000-0003-0661-6984)
- Christian Riehle (ORCID: https://orcid.org/0000-0002-0040-4254)
- Maren Heimerl
- Danny Jonigk (ORCID: https://orcid.org/0000-0002-5251-2281)
- Robert Geffers (ORCID: https://orcid.org/0000-0003-4409-016X)
- Paolo Galuppo (ORCID: https://orcid.org/0000-0001-6745-5681)
- Viacheslav O. Nikolaev (ORCID: https://orcid.org/0000-0002-7529-5179)
- Ivanna Shymotiuk
- Christopher Werlein (ORCID: https://orcid.org/0000-0002-7694-4257)
- Jan Hegermann (ORCID: https://orcid.org/0000-0001-7893-8507)
- Sergej Erschow
- Tim Scholz (ORCID: https://orcid.org/0000-0002-2127-9843)
- Felix Polten (ORCID: https://orcid.org/0000-0002-1076-5272)
- Kai C. Wollert (ORCID: https://orcid.org/0000-0002-4890-4450)
- Adam R. Wende (ORCID: https://orcid.org/0000-0002-5536-4675)
- Anna Gigina
- Andreas Pich
- Mortimer Korf-Klingebiel
- Melanie Ricke-Hoch
- Katharina Wihler
- Jonas Jablinski
- E. Dale Abel
- Johann Bauersachs
Institutions
- Universität Hamburg (DE)
- UCLA Health (US)
- University Medical Center Freiburg (DE)
- University of Alabama at Birmingham (US)
- Medizinische Hochschule Hannover (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Helmholtz Centre for Infection Research (DE)
- German Center for Lung Research (DE)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1161/circresaha.125.327297
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00