CRLF1 Secreted by Cardiac Fibroblasts Promotes Human Hypertrophic Cardiomyopathy
Our findings uncover a common, nongenetic paracrine mechanism underlying HCM pathogenesis and establish CRLF1 as a promising universal therapeutic target for this heterogeneous disease.
Authors
- Jie Yang (ORCID: https://orcid.org/0000-0003-4399-2532)
- Dan Shi (ORCID: https://orcid.org/0000-0003-0138-3958)
- Lingjie Hu
- Meiting Shen
- Can Li (ORCID: https://orcid.org/0000-0002-9412-4412)
- Bowen Lin (ORCID: https://orcid.org/0009-0000-7105-4872)
- Ying Liu
- Yi-Han Chen
- D Wang
- Mo Zhang
- Fanhong Zhou
- Jizheng Wang
- Bin Zhou
- Lei Chen
- Shuiyun Wang
- Guoliang Xu
- Lei Song
Institutions
- Tongji University (CN)
- Heart Rhythm Society (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Center for Excellence in Molecular Cell Science (CN)
- Shanghai East Hospital (CN)
- Fu Wai Hospital (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1161/circulationaha.125.075290
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00