Integrated single-cell and spatial analysis reveals context-dependent myeloid-T cell interactions in response to immune checkpoint blockade in head and neck cancer
We have provided a valuable resource for analyzing spatial and cell-cell ligand-receptor interactions, including the cellular and spatial contexts of ICB response markers. Our data suggest that future mechanistic studies should consider this context specificity when evaluating ICB response biomarkers and targets.
Authors
- Taja Ložar (ORCID: https://orcid.org/0000-0003-2893-5580)
- Paul M. Harari (ORCID: https://orcid.org/0000-0002-6207-5505)
- Paul F. Lambert (ORCID: https://orcid.org/0000-0001-7983-2755)
- Athena E. Golfinos (ORCID: https://orcid.org/0000-0002-8365-1743)
- Evan Johns
- Huy Q. Dinh (ORCID: https://orcid.org/0000-0002-3307-1126)
- Megan B. Fitzpatrick (ORCID: https://orcid.org/0000-0001-7040-8018)
- Parth Khatri
- Rong Hu
Institutions
- University of Wisconsin–Madison (US)
- Institute of Oncology Ljubljana (SI)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2300
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00