Curcumol Induces G1 Phase Arrest in SK-Hep-1 Cells by Targeting SKP2-Mediated p27 Degradation
Curcumol reduced SKP2 expression, weakened the interaction between SKP2 and p27, inhibited degradation of p27, and then induced G1 phase cell-cycle arrest in SK-Hep-1 cells.
Authors
- Rui Ai (ORCID: https://orcid.org/0000-0002-3224-008X)
- J Wang
- Zhi Cui (ORCID: https://orcid.org/0000-0002-4832-6558)
- Zheng Liu (ORCID: https://orcid.org/0000-0002-4252-4617)
- Tong Dou
- Yizhuang Yang
- Yue Zhao
- Xu Chen
- Riqiu Zhang
Institutions
- Macau University of Science and Technology (MO)
- Guilin Medical University (CN)
Publication Details
- Journal
- Molecules
- Published
- 2026-03-16
- DOI
- https://doi.org/10.3390/molecules31060997
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00