Examining the gene network and prognostic biomarkers in the onset of colorectal cancer in stool samples using machine learning

Colorectal cancer is a major cause of morbidity and mortality worldwide. Early detection and diagnosis are critical for effective treatment, and the identification of prognostic biomarkers is essential for predicting patient outcomes. Recent advances in machine learning have enabled researchers to analyze large datasets of genomics and clinical data to identify novel biomarkers and therapeutic targets. In this study, we aim to examine the gene network and prognostic biomarkers involved in the onset of colorectal cancer in stool samples using machine learning. We will analyze data from a cohort of patients with colorectal cancer and healthy controls, including genomic data, clinical data, and stool samples. We will use a variety of machine learning techniques, including deep learning and network analysis, to identify patterns and relationships between genes, biomarkers, and clinical outcomes. Our preliminary results suggest that machine learning can be used to identify novel biomarkers and gene networks associated with the onset of colorectal cancer in stool samples. We have identified several candidate biomarkers that are significantly associated with disease progression and patient outcomes. These findings have the potential to improve our understanding of the molecular mechanisms underlying colorectal cancer pathogenesis and to identify new targets for therapy. In conclusion, our study demonstrates the feasibility and utility of using machine learning to analyze complex datasets of genomics and clinical data in the context of colorectal cancer. We anticipate that this approach will lead to the development of more accurate prognostic biomarkers and personalized therapies for patients with colorectal cancer.

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Publication Details

Journal
Discover Oncology
Published
2026-03-16
DOI
https://doi.org/10.1007/s12672-026-04773-z
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
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article

Examining the gene network and prognostic biomarkers in the onset of colorectal cancer in stool samples using machine learning

Amir‐Reza Javanmard, Amir Khanmirzaei, Atefeh Noori, Bahar Karimikhoshnoudian et al.
Discover Oncology
Ferroptosis and cancer prognosis
article

Examining the gene network and prognostic biomarkers in the onset of colorectal cancer in stool samples using machine learning

Amir‐Reza Javanmard, Amir Khanmirzaei, Atefeh Noori, Bahar Karimikhoshnoudian, Tabasom Hassania, Nasim Amirnia, Mohaddese Sadat Mahmoudi, Reza Shaghaghi Shahr, Fatemeh Karimpour, Paniz Nasiri
article en

Abstract

Colorectal cancer is a major cause of morbidity and mortality worldwide. Early detection and diagnosis are critical for effective treatment, and the identification of prognostic biomarkers is essential for predicting patient outcomes. Recent advances in machine learning have enabled researchers to analyze large datasets of genomics and clinical data to identify novel biomarkers and therapeutic targets. In this study, we aim to examine the gene network and prognostic biomarkers involved in the onset of colorectal cancer in stool samples using machine learning. We will analyze data from a cohort of patients with colorectal cancer and healthy controls, including genomic data, clinical data, and stool samples. We will use a variety of machine learning techniques, including deep learning and network analysis, to identify patterns and relationships between genes, biomarkers, and clinical outcomes. Our preliminary results suggest that machine learning can be used to identify novel biomarkers and gene networks associated with the onset of colorectal cancer in stool samples. We have identified several candidate biomarkers that are significantly associated with disease progression and patient outcomes. These findings have the potential to improve our understanding of the molecular mechanisms underlying colorectal cancer pathogenesis and to identify new targets for therapy. In conclusion, our study demonstrates the feasibility and utility of using machine learning to analyze complex datasets of genomics and clinical data in the context of colorectal cancer. We anticipate that this approach will lead to the development of more accurate prognostic biomarkers and personalized therapies for patients with colorectal cancer.

Discover Oncology
Tarbiat Modares University (IR), Shahid Sadoughi University of Medical Sciences and Health Services (IR), Islamic Azad University Medical Branch of Tehran (IR), Iranian Research Organization for Science and Technology (IR), Shahid Beheshti University (IR), Shahid Beheshti University of Medical Sciences (IR), Babol University of Medical Sciences (IR)
Good health and well-being
Openalex Percentile: Top 21%
Ferroptosis and cancer prognosis
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