Task-based functional connectivity in striato-motor-cortical system in autism: Associations with sex and executive function

We previously found that female autistic people show differences in a part of the brain called the striatum. Some parts of the striatum connect to the frontal lobe of the brain, and may help people control their attention and behavior. We studied how the striatum "talked to" the frontal lobe in autistic girls. We found out that this communication is lower in autistic than non-autistic girls. We also found out that how much striatum "talks to" frontal lobe helps explain differences in how well both autistic and non-autistic youth of both sexes control their attention and behavior.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-03-16
DOI
https://doi.org/10.64898/2026.03.13.711578
Primary Topic
Autism Spectrum Disorder Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Task-based functional connectivity in striato-motor-cortical system in autism: Associations with sex and executive function

Abha Rani Gupta, Allison Jack
bioRxiv (Cold Spring Harbor Laboratory)
Autism Spectrum Disorder Research
article

Task-based functional connectivity in striato-motor-cortical system in autism: Associations with sex and executive function

Abha Rani Gupta, Allison Jack
article en

Abstract

We previously found that female autistic people show differences in a part of the brain called the striatum. Some parts of the striatum connect to the frontal lobe of the brain, and may help people control their attention and behavior. We studied how the striatum "talked to" the frontal lobe in autistic girls. We found out that this communication is lower in autistic than non-autistic girls. We also found out that how much striatum "talks to" frontal lobe helps explain differences in how well both autistic and non-autistic youth of both sexes control their attention and behavior.

bioRxiv (Cold Spring Harbor Laboratory)
George Mason University (US), Yale University (US)
National Science Foundation, George Mason University, Australian Government, National Institutes of Health, National Institute of Mental Health
Gender equality
Openalex Percentile: Top 25%
Autism Spectrum Disorder Research
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Task-based functional connectivity in striato-motor-cortical system in autism: Associations with sex and executive function — Abha Rani Gupta, Allison Jack · bioRxiv (Cold Spring Harbor Laboratory) (2026) | TGRS Research Map | TGRS