The impact of fulvestrant on estrogen receptor-driven chromatin dynamics in breast cancer cells
This study provides new insights into the mechanistic impact of FULV on ER activity, highlighting its ability to modulate H3K27ac dynamics even in the absence of transcriptional changes. These findings underscore the complexity of ER signaling and further suggest that FULV's therapeutic effects may extend beyond simple antagonism of ER activity.
Authors
- Mathias Simplicien (ORCID: https://orcid.org/0000-0001-9303-5584)
- Vincent Piras (ORCID: https://orcid.org/0000-0002-3427-0995)
- Gurpreet Bharaj (ORCID: https://orcid.org/0000-0002-8205-6547)
- Célia Fontana
- Gaylor Boulay (ORCID: https://orcid.org/0009-0001-7466-0760)
- Ana Hermoso
- Céline Barlier (ORCID: https://orcid.org/0000-0002-0975-2925)
- Aurélia Delherme
- Andreas Vogt (ORCID: https://orcid.org/0000-0001-6846-9292)
- Natalie Daluege
- Anais Pourrat
- Isabel Paiva
- Elsa Moreau
- Coralie Hoareau-Aveilla
- Cibele de Oliveira
Institutions
- Hamburg Institut (Germany) (DE)
- Evotec (United States) (US)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1186/s13072-026-00667-0
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00