Reduced Rate of Complications With Transperineal Prostate Biopsy: Real-world Data From a National Cohort Derived From the Danish Prostate Cancer Registry

This population-based study provides real-world evidence on complication rates following the transition from transrectal to transperineal (TP) prostate biopsy. Adoption of the TP technique was associated with a substantial reduction in 7-d postbiopsy hospitalizations (from 6% to 1%), despite discontinuation of routine antibiotic prophylaxis. These findings underscore the safety advantages of the TP approach and support its establishment as the clinical gold standard.