Neuropsychiatric Symptom Clusters and Their Association With Brain Structure in Alzheimer Disease
<b>Conclusion:</b> NPS in AD separate into hyperactivity, psychosis, neurovegetative, and affective clusters, supporting a cluster-based paradigm linking co-occurring behavioral symptoms with brain structure and functional decline.
Authors
- Paula McLaughlin (ORCID: https://orcid.org/0000-0001-7173-8449)
- Lorne Zinman (ORCID: https://orcid.org/0000-0002-8096-8366)
- Agessandro Abrahão (ORCID: https://orcid.org/0000-0003-1142-2842)
- Gustavo Saposnik (ORCID: https://orcid.org/0000-0002-5950-9886)
- J. B. Orange (ORCID: https://orcid.org/0000-0002-2632-3049)
- David Tang-Wai
- Neda Rashidi-Ranjbar
- Angela Roberts
- Anthony Lang
- Wang, Wei Neng; Chang, Juin Jen; Shieh, Jhy Yuan; Chen, Jhy Hwa
- Mario Masellis
- Tarek K. Rajji
- Corinne E. Fischer
- Sanjeev Kumar
- Daniel Kapustin
- Angela Troyer
- David Grimes
- Richard H. Swartz
- Connie Marras
- Malcolm A. Binns
- Maria C. Tartaglia
Institutions
- Northwestern University (US)
- Western University (CA)
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Health Sciences Centre (CA)
- Nova Scotia Health Authority (CA)
- Baycrest Hospital (CA)
- MIND Research Institute (US)
- Occupational Cancer Research Centre (CA)
- Public Health Ontario (CA)
- Croatian Forest Research Institute (HR)
- Ontario Brain Institute (CA)
Publication Details
- Journal
- The Journal of Clinical Psychiatry
- Published
- 2026-03-16
- DOI
- https://doi.org/10.4088/jcp.25m16192
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00