β2-microglobulin amyloid deposition and the RAGE-related inflammation pathway in ligamentum flavum thickening among patients undergoing hemodialysis: a comparative cross-sectional study from Japan
LF in HD patients exhibits B2M amyloid and AGE accumulation with upregulation of RAGE-related inflammatory genes and proteins, especially on the dorsal side. LF hypertrophy in dialysis-related LSCS appears to represent an inflammatory-amyloid phenotype, indicating the AGE-B2M-RAGE pathway as a potential therapeutic target.
Authors
- Yoshito Onoda (ORCID: https://orcid.org/0000-0001-6904-4595)
- Takahiro Onoki (ORCID: https://orcid.org/0000-0001-9934-9656)
- Ko Hashimoto
- Yutaka Yabe
- Keisuke Ishikawa
- Kohei Takahashi
- Toshimi Aizawa
Institutions
- Tohoku University (JP)
- Sendai Nishitaga National Hospital (JP)
Publication Details
- Journal
- Asian Spine Journal
- Published
- 2026-03-17
- DOI
- https://doi.org/10.31616/asj.2025.0595
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00