Weight Regain Reverses Caloric Restriction–Induced Benefits on the Insulin–IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial
Substantial weight loss followed by weight regain can attenuate or reverse CR-induced benefits on key regulators of the insulin-IGF-1 nutrient-sensing pathway and markers of biological aging. Sustained, moderate weight loss more effectively improves insulin resistance and maintains favorable hormonal profiles linked to type 2 diabetes risk and aging biology.
Authors
- Calen P. Ryan (ORCID: https://orcid.org/0000-0002-0550-7949)
- Moritz V. Warmbrunn (ORCID: https://orcid.org/0000-0003-3548-6728)
- Raaj Kishore Biswas (ORCID: https://orcid.org/0000-0003-4294-6323)
- Luigi Fontana (ORCID: https://orcid.org/0000-0003-3877-0417)
- Amy Harper
- Giovanni Fiorito
- Lin Yang
- Daniel W. Belsky
Institutions
- Alberta Health Services (CA)
- The University of Sydney (AU)
- University of Calgary (CA)
- Royal Prince Alfred Hospital (AU)
- South Health Campus (CA)
- Istituto Giannina Gaslini (IT)
- UNSW Sydney (AU)
- Alberta Cancer Foundation (CA)
- Amsterdam University Medical Centers (NL)
- Imperial College London (GB)
- Columbia University (US)
Publication Details
- Journal
- Diabetes Care
- Published
- 2026-03-16
- DOI
- https://doi.org/10.2337/dc25-1911
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00