Macroscale Gradient‐Informed Neural Oscillation Topography in Parkinson's Disease
This work demonstrates that PD induces a macroscale reorganization of the cortical hierarchy. State-dependent topographical biomarkers effectively predict clinical severity and align with the disease pathological landscape. By identifying optimal sensing sites across distributed networks, our findings provide a principled reference to support next-generation, cortical-guided aDBS. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Manuel Bange (ORCID: https://orcid.org/0000-0002-5247-8810)
- Ke Xie (ORCID: https://orcid.org/0000-0002-7101-2493)
- Bahman Nasseroleslami (ORCID: https://orcid.org/0000-0002-2227-2176)
- Jens Volkmann (ORCID: https://orcid.org/0000-0002-9570-593X)
- Jenny Blech
- Muthuraman Muthuraman
- Sergiu Groppa
- Hannah Kühne
- Hao Ding
Institutions
- Montreal Neurological Institute and Hospital (CA)
- University of Augsburg (DE)
- Johannes Gutenberg University Mainz (DE)
- Trinity College Dublin (IE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Universitätsklinikum Würzburg (DE)
- Saarland University (DE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1002/mds.70277
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00