Single-cell RNA sequencing reveals the heterogeneity and intercellular communication of endothelial cells and Schwann cells during keloid formation

This study highlights the distinct heterogeneity and dynamic intercellular interaction between endothelial cells (ECs) and Schwann cells (SCs) in the pathogenesis of keloids. The identification of tumor-like endothelial subclusters and their regulatory networks provides novel insights into keloid biology and suggests PLPP3 as a potential target for therapeutic intervention.